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Discussion The quest for an effective pre-erythrocytic LS stage malaria vaccine needs long-lasting humoral and cellular immunity

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Finally, several metabolic diseases such as aminoaciduria, organic aciduria, urea cycle and fatty acid oxidation defects, mitochondrial disorders and acute intermittent porphyria should be ruled out ( Because of the wide range of underlying conditions and lack of a specific sign and biomarker of CVS, the selection of first step and progression of investigations is often challenging and tests should be selected based on clinical presentation and suspicion (Tables 35)

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